Absolutely amazing! We have an excruciatingly high-strung, seemingly nocturnal dog that feels the need to be taken out several times a night. We take his water away hours before the night comes to an end, potty right before bed, all the boxes checked. He just barks & screams & wakes the whole house (kids, old man dog….). We’ve made sure there are no issues causing this…nope…he’s just a maniac. I stumbled upon these at the local pet supply, did some homework & went for it. Oh. My. Stars!!! Night one, low end of low dose just to try &…..pure bliss. He slept until our 5am waking. I was SHOCKED! Top it off with the dental benefits & fresh breath……..we can’t thank you enough!!!!